Formulation of promising antibacterial, anticancer, biocompatible and bioactive biomaterial as therapeutic drug delivery system for biologically active compound loaded on clay polymer

Abstract The synthesized heterocyclic compound: 5-[4-bromobenzylidene amino)-1, 3, 4-thiadiazole-2-thiol abbreviated as BATT possessed good antibacterial activity for various Gram-negative and Gram-positive bacteria. In addition to potent antitumor breast cancer, the first time, novelty of this study is facile low-cost formulation safe drug delivery system (DDS) cancer from such simple compound. Heterocyclic compound efficiently spontaneously incorporated into MMT clay polymer matrix forming novel therapeutic nanocomposite DDS cancer. successfully intercalates matrix. Electron donation ability nanocomposites confirmed by cyclic voltammetry in terms small peak-to-peak redox potential $$\Delta E_{{{\text{peak}}}}$$ Δ E peak . Adsorption on carried out batch adsorption method. Better strength at low pH 2 decreased with increasing pH. data are analyzed multiple mathematical models. an efficient carrier heterogonous adsorbent optimum conditions: contact time 2.0 h, initial concentration up 1200 ppm. rate constant, k equals 14.6 $$\times$$ × 10 –3 q e 19 mg g −1 ( R 0.999). zero charge 3 reflected mechanism MMT. At 2, loaded physi- chemisorption. 4,